Transfer of DNA into cells is used for bacterial transformation, eukaryotic tissue culture cell or primary tissue cell transfection, as well as production of transgenic animals. The Hope lab is involved in collaborative projects with Mechanical Engineering to pursue new technologies in macromolecule transfer using micro-electro-mechanical systems on the nanometer scale utilizing small silicone chips and nanotechnology. This collaboration has resulted in the development of ‘nanoinjection,’ a new method for producing transgenic mice using simplified operational techniques and resulting in reduced cell trauma.
The Hope lab is also actively engaged in the study of mycobacteriophage, and phage hosted by other bacteria. The research is in continuation of an undergraduate research course titled, “Phage Hunters,” which attempts to capture, purify, and sequence whole genomes of novel phage from environmental samples such as soil.